Human Tissues Become Microbes Alen J Salerian MD

                      Human Tissues Become Microbes

Hereby , in the spirit of  helping people with burn wound  and opportunistic infections  , I share my observations that, human tissues may become microbes.

             Alen J Salerian MD

                            

Louis Pasteur’s germ theory (1) and the Nobel winning discovery by Drs Barry Marshall and Robin Warren  that H .pylori bacteria cause gastric ulcers (2) are ground breaking achievements in medicine. Of scientific significance, they  also share a common  observation :Bacterial contamination is an exclusive source of infections .

  I suggest , not only contamination but also pathways independent of contamination produce bacterial and fungal growth (3). The following  are the evidence :

A.    First bacteria were transformed from lifeless organic matter (4,5,6).

B.    A protein transforms to a virulent pathogen to cause bovine spongiform encephalopathy (7).

C.     Gastric ulcers can be experimentally induced without contamination (8,9), heal spontaneously (8,9) and be effectively treated without antibacterial treatment (10,11) . This suggests ,h. pylori ,the causative pathogen of gastric ulcers  may result from gastric organic matter.

D.    Host genetics are the predominant influence in gut microbiota (12).This suggests gut microbiota may originate from host cells.

E.     Tinea versicolor infections are not contagious(13,14,15 ) , can be experimentally induced by administration of anti-inflammatory medications(13,14)  and host biology and genetics predetermine their development(13,14). Furthermore, although amniotic fluid(16) and  infant skin at birth(17) are  free of malassezia yeasts , and It is not possible to infect humans by inoculation of malassezia yeasts without occlusion (!8,19), infant skin harbor them in the first week (17). These findings suggest , pathways independent of contamination produce malassezia colonization and infections.

F.     Bacteria in breast milk are morphologically different than bacteria in amniotic fluid, placenta, meconium and umbilical cord blood and they are not contaminants(20-25). Also breast milk contains  essential organic matter for life and ,empirical observations suggest unrefrigerated sterilized eggs and milk go sour(this observation has not been experimentally validated ). These observations suggest , bacteria in breastmilk result from transformation of organic matter.

G.    Mathematical evidence suggest the probability of pathways independent of contamination to cause burn wound infections is % 99.9999.(26)

 Collectively, the evidence indicate infections result from contamination or by transformation of organic matter of human tissues to microbes. This observation may promote new insights into the complex relations among living and nonliving things.

References :

1.Pasteur L. And the extension of the germ theory to the aetiology of certain common diseases. Comptes rendus  del’Academie des Sciences.xc.Ernst,(Ttrans).1880;1033-44.H.C.

2. Marshall BJ, Warren JR (June 1984). "Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration". Lancet. 1 (8390): 1311–5.

3. .Salerian A.J.,Human body may produce bacteria. Medical Hypotheses, 103: 130-132, June 2017 .

4. . Schopf J.W.,Fossil evidence of Arcaean Life, philosophical transactions of the Royal Society biological sciences. June 29, 2006. Volume 361, issue 1470.

5. Cavalier-Smith T., Cell evolution and Earth history :Stasis and revolution. Philosophical transactions Royal Society in London biological sciences. 2006 June 29;; three six one(1470) 969 – 1006.

6.  Altermann W., Kazmieczak J., .Archean Micro fossils: a reappraisal ofr early life on earth. Researching microbiology. Volume 154, issue 9, November 2003  page is 611 – 617.

7. Brown P.,Will R.G., Bradley R., Asher D.M.,Detwiler L., Bovine spongiform encephalopathy and variant Creutzfeldt- Jacob disease:  background evolution and current concerns, emerging infectious diseases volume 7 number 1, January – February 2001.

8.  HAY, L. J. ;  VARCO, R. L. ;  CODE, C. F. ;  WANGENSTEEN, O. H.The experimental production of gastric and duodenal ulcers in laboratory animals by the intramuscular injection of histamine in beeswax. : Surgery, Gynecology and Obstetrics 1942 Vol.75 pp.170-182.

9.Huang J-Q.,Sridhar S.,Hunt R., Role of helicobacteri infection and none steroidal anti-inflammatory drugs in peptic ulcer disease; and meta-analysis. The Lancet.,2002 , volume 359 issue 9300, Pages 14 – 22.

10. Perri F.,Pastore M.,Rocco C.,et al.,Helicobacteri  pyloriinfection may undergo spontaneous eradication in children:A2 year follow up study. Journal of pediatric gastroenterology and nutrition. 27(2): 181-183, August 1998.

11. Harry H .X., Talley ,N.J., Natural acquisition and spontaneous illumination helicobacter pylori infection :clinical implications. American Journal of gastroenterology October 1997 volume 92 issue 10 Pages 1780 – 1787.

12. Morgan A. G.,  McAdam, W A., Pacsoo,  C., Walker B.E., Simmons A.V.,

 Cimetidine: an advance in gastric ulcer treatment? Br Med J 1978;2:

13. Isenberg,J.I.,, Peterson,W.L., Elashoff,J.D., Sandersfeld,M.A.,et.al.,  Healing of    Benign Gastric Ulcer with Low-Dose Antacid or Cimetidine — A DoubleBlind, Randomized, Placebo-Controlled Trial, N Engl J Med 1983; 308:1319-1324

14, Khatchataryan Z.A.,Ktsoyan Z.A.,Manukyan G.P.,Kelly D.,Ghazaryan K.A.,Aminov R.I., predominant role of host genetics in controlling the composition of gut .microbiota.PLoS One 2008;3:e3064.

15.He S.M., Du W.D., Yang S., Zhou S.M., Li W., Wang J., Xiao F.L., Xu S.X., Zhang X.J., The genetic epidemiology of tinea versicolor in China. Mycosis/ volume 51/ issue one. October 2007.

16. Hafez Ma · El-Shamy SB , Genetic Susceptibility in Pityriasis versicolor, Dermatologica 1985;171:86–88.

17 Burke,R., Tinea Versicolor: susceptibility factors in experimental infection in human beings. Journal of investigative dermatology. 1961, volume 36 number 5, Pages 389 – 401.

18. Digiullo D.B., .Diversity of microbes in amniotic fluid. Seminars in fetal and neonatal medicine. Volume 17, issue 1, February 2012 pages 2

 19. Capone K.A.,Dowd S.E.,Stamatas G.N.,Nikolovski J.,Diversity of the human skin microbiome early in life.J Invest Dermatolo ,2011.131(10)206-2032.

20.  Cabanes F.J(2014),Malassezia yeasts:how many species infect humans and animals ?PLOS Pathogens,10(2):e1003892. 


21.   Faergemann J., Fredricksson T., Experimental infections in rabbits and humans with Pityrosprum orbiculare and P.ovale. Journal of Investigative Dermatology. Volume 77 issue 3, September 1981, Pages 314 – 318.

22.   FaergemannJ.,AlyR.,WilsonD.R.,MaibachH.I.,;Skinocclusion:effectonPityrosprum orbiculare,skinP-CO2,ph, trans epidermal water loss, and water content. Archives of dermatological research. November 1983, volume 275, issue 6, pages 383 – 387.

23.  Cabrera-Rubio R., Collado M.C.,Laitenen K., Salminen S., Isolauri E., The human milk microbiome changes over lactation and is shaped by maternal weight and mode of delivery. The American Journal of clinical nutrition volume 96, issue 3, September 2012, page is 544 four four– 551.

24.   Martin R.,Langa S., Revriego C., et al .Human milk is a source of lactic acid bacteria for the infant gut. The Journal of pediatrics. December 2003, volume 143, issue six, Page is 754 – 758

25.  Urbaniaak,C.et al. Microbiota  in human breast tissue. Appl.Environ. Microbiology 80, 3007 – 3014(2014).

26.  .Salerian A.J., pathways independent of contamination may produce burn wound infections. Biomedical Journal of scientific and technical research. Volume 8-issue five:2018.