Do Human Stem Cells Produce Bacteria?

Do Human Cells Make Bacteria? Recent Discoveries Some human infections are caused by microbes produced by human cells HIGHLIGHTS • Human stem cells differentiate to epithelial and cancer cells and have the properties to produce microbes. • Breast tissue ,breast milk, amniotic fluid, meconium, placenta, umbilical cord blood harbor bacteria that are not contaminants from the environment. • Some gut bacteria are heritable and human genetics shape gut bacteria. • Malassezia furfur yeasts- which belong to normal human skin flora are heritable. Where do bacteria and viruses come from? Science says modern humans emerged in East Africa 56,000 years ago, long after bacteria were born from lifeless Earth 3.6 billion years earlier (1). How about viruses; when did they emerge? It is reasonable to speculate that viruses were born long after bacteria for they are things that may be viewed as dead or alive depending on their environment. This is because viruses require a cell of a multi -cellular organism to reproduce (2). Virion Is a lifeless protein particle that can reproduce inside a human or animal cell. When a virion is absorbed by a human or animal cell it is now transformed to a living virus that can reproduce. The emphasis here is the absorption or assimilation of a lifeless protein particle into a cell. Here comes an interesting observation about viruses and bacteria: human body and cells seem to be capable to produce pathogens that infect other humans and trigger epidemics around the world for we have also discovered that human stem cells are capable to produce bacteria and are responsible for major endogenous infections as diverse as burn wound infections , nosocomial and opportunistic infections (3-8). How did this novel finding come about? The first clue of human stem cells being an infinite source of microbes came from the observation that some gut bacteria were heritable (9,10,11) suggesting a genetic link between human cells and bacteria. Also, of significance was the discovery that the fetus which had been presumed to be sterile harbored bacteria and as importantly these endogenous microbes were not contaminants from the environment (12,13,14,15). The dual discoveries- none sterile fetus and heritable bacteria -prompted a question: which human cells are the most likely candidates to produce bacteria ? Interestingly, we for some time had known that human stem cells could differentiate to epithelial and cancer cells (16,17).Thus , it can be inferred that stem cells may be the creator of endogenous microbes and infections. Here is a synopsis of all of the above: Long after the Big Bang , the first bacteria were born to evolve to plants ,fish, mammals and to modern humans whose stem cells began manufacturing microbes. Nowadays, not only microbes reproduce but humans too generate microbes but because paradigm shifts in science are always slow we continue to blame foreign pathogens for making us sick. References: 1. Cavalier-Smith T., Cell evolution and Earth history :Stasis and revolution. Philosophical transactions Royal Society in London biological sciences. 2006 June 29;; three six one(1470) 969 – 1006. 2. Breitbatr M ,Rohwer F . "Here a virus, there a virus, everywhere the same virus?".(2005) Trends in Microbiology. 13 (6): 278–84 3. Salerian AJ, Human body may produce bacteria,Medical Hypotheses, Volume 103, June 2017, Pages 131-132. 4. Salerian, Alen, Gastric Ulcers May Result From Transformation of Human Tissue to H. pylori: Mathematical Evidence (January 8, 2018). Available at SSRN: https://ssrn.com/abstract=3225494 or http://dx.doi.org/10.2139/ssrn.3225494 5. Salerian AJ, Burn wound infections and Pseudomonasaeruginosa,Burns;46(1):257-258,2020 02 6. Salerian AJ,What is the origin of human bacterial flora? Journal of Applied & Environmental Microbiology, 2020, Vol. 8, No. 1, 1-5 . 7. Salerian AJ., Was Pasteur Wrong? Human Cells may Generate Bacteria. Biomed J Sci &Tech Res 4(5)- 2018. BJSTR.
 8. Salerian AJ.,Infections Independent of Contamination: From Organic Matter, Evolution or Stem Cells, APPLIED CELL BIOLOGY,November 2021 9. Khatchataryan Z.A., Ktsoyan Z.A.,Manukyan G.P.,Kelly D.,Ghazaryan K.A.,Aminov R.I.,predominant role of host genetics in controlling the composition of gut .microbiota.PLoS One 2008;3:e3064. 10. Waters, J.L., Ley, R.E. (2019). The human gut bacteria Christensenellaceae are widespread, heritable, and associated with health. BMC Biol 17, 83 . 11. Goodrich,JK, Waters JL, Poole AC , Human Genetics Shape the Gut Microbiome, Cell(2014),Volume 159, Issue 4,Pages 789-799. 12. Martin R, Langa S, Reviriego C et al., Human milk is a source of lactic acid bacteria for the infant gut. The Journal of Pediatrics.(2003) Volume 143, issue 6, Pages 754-758. 13. Urbaniaak,C. Cummins J, Brackstone M , Macklaim J M , Gloor G B, Baban C K , Scott K ,et al. 2014. Microbiota in human breast tissue. Appl.Environ. Microbiology 80, 3007 – 3014. 14. Jiménez, E., Fernández, L., Marín, M.L. et al. Isolation of Commensal Bacteria from Umbilical Cord Blood of Healthy Neonates Born by Cesarean Section. Curr Microbiol 51, 270–274 (2005). 15. Stout MJ,, Conlon B, Landeau M, Lee I, Bower C, Zhao Q, Roehl KA, Nelson DM,. Macones GA, I Mysorekar IU,(2008) .Identification of intracellular bacteria in the basal plate of the human placenta in term and preterm gestations,American Journal of Obstetrics and Gynecology,Volume 208, Issue 3, 16. Van der Flier LG,Clevers H,,Stemcells,Self Renewal,and Differentiation in the intestinal Epithelium, Annual Review of Physiology(2009) 71:1,24-260. 17. Reya, T., Morrison, S., Clarke, M. et al. Stem cells, cancer, and cancer stem cells. Nature 414, 105–111 (2001).

SCOUTING REPORT or BEDLAM in Greece

Scouting Report or Bedlam in Greece?

During a commercial TV break of a Premier league football game between Manchester United and Everton , four well known reporters of Scouting Report of Sports Channel- with a Dr. Freud photo in the background suggesting mental troubles- made not so funny faces, accompanied by eerie mannerisms of grief and misery; they were presenting sports news by mixing humor with football images. I was unhappy about their offensive humor .I was not alone; my friend visiting from Washington D.C, a father of a 12 -year-old son with Down Syndrome, asked me whether it was common practice in Athens, to make fun of people with mental disabilities. I understood his pain recalling human history full of shameful chapters of abuse , discrimination against and ridicule of people with emotional disorders . It was indeed as late as in the second half of 19th century in England at Bedlam where chained psychiatric patients served as subjects of entertainment : on special weekends visitors would pay a special fee to watch victims of psychotic disorders . Photo: William Norris , Bedlam patient 1815 So as if, discrimination against people with imperfect brains has also evolved. Now we have television reporters broadcasting prejudice. Here are some questions I have for the fellows from the Scouting Report: Will you educate the public about prejudice against people with mental illness? Do you know anyone with mental illness? What’s so funny about making fun of people with imperfect brains? The mother of prejudice against people with mental illness is ignorance and is the same toxin that governs grotesque acts of ethnic, racial or religious hatred. So this is Greece 2021. The birth place of democracy, Socrates, Plato and Hippocrates. Let us hope, ignorant ridicule of people with mental illness has not place anywhere in the world including Greece.

witch hunt of pain doctors

SEPTEMBER 23,2021 Dear Friends U.N. will be holding a panel discussion on the persecution and witchhunt of pain doctors in America. Please just spread the word and let others know. THANKS ALEN J SALERIAN MD To: The Law Project Greetings! As part of the Global Week of Action spearheaded by the U.N. Sustainable Development Goals (SDG) Action Campaign, National Judicial Conduct and Disability Law Project, Inc. (NJCDLP) is hosting a half-day online conference on its campaign, Opt IN USA Our first two hours will guide attendees through documented, national patterns of organized U.S. legal system abuse facilitated by unchecked judicial misconduct and the confirmed, related violation of America’s International Covenant on Civil and Political Rights (ICCPR). Is the solution compliance with U.N. guidelines on the right to a remedy and reparations for Americans accordingly left with ineffective domestic avenues of redress for persistent U.S. legal system abuse? Via a one (1) hour round table discussion our distinguished panelists will weigh-in on whether adherence to those guideline detailed by U.N. General Assembly Resolution 60/147 is the “Turning Point” our nation needs for individual, collective, and government healing. Kindly learn more and register to join this September 25, 2021 event: CLICK HERE or paste in your browser @ https://www.act4sdgs.org/profile/NJCDLP_TheLawProject

A Very Brief History of Life on Earth

some dreams come true

SOME DREAMS COME TRUE

Not all dreams come true True are some dreams Some like formula 1 races Jaguars are hunting Not that giraffes and zebras easy prey You see when traveling fast Your grandma and strangers Look like dots far away Till smell of blood and tires But this poem is not about cars What’s so enchanting Uplifting moments No mass killings we call wars When humans are dots Reason shall triumph some day Here is some good news Triumphant trumpets marching All wars banned Joyful gorillas in air Bursting with pride Some can’t believe Jungle without homicides Some dreams come true Feels so marvelous Never ever awaken me Let us evolve Let us be Let sun rise for reason