Human
Tissues Become Microbes
Hereby , in the spirit of helping people with burn wound and opportunistic infections , I share my observations that, human tissues
may become microbes.
Alen J
Salerian MD
Louis Pasteur’s germ theory (1) and
the Nobel winning discovery by Drs Barry Marshall and Robin Warren that H .pylori bacteria cause gastric ulcers (2)
are ground breaking achievements in medicine. Of scientific significance, they also share a common observation :Bacterial contamination is an
exclusive source of infections .
I suggest
, not only contamination but also pathways independent of contamination produce
bacterial and fungal growth (3). The following are the evidence :
A.
First bacteria were transformed from
lifeless organic matter (4,5,6).
B.
A protein transforms to a virulent pathogen to
cause bovine spongiform encephalopathy (7).
C.
Gastric ulcers can be experimentally induced
without contamination (8,9), heal spontaneously (8,9) and be effectively treated
without antibacterial treatment (10,11) . This suggests ,h. pylori ,the
causative pathogen of gastric ulcers may
result from gastric organic matter.
D.
Host genetics are the predominant influence in
gut microbiota (12).This suggests gut microbiota may originate from host cells.
E.
Tinea versicolor infections are not contagious(13,14,15
) , can be experimentally induced by administration of anti-inflammatory
medications(13,14) and host biology and
genetics predetermine their development(13,14). Furthermore, although amniotic fluid(16) and infant skin at birth(17) are free of malassezia yeasts , and It is not
possible to infect humans by inoculation of malassezia yeasts without occlusion
(!8,19), infant skin harbor them in the first week (17). These findings suggest
, pathways independent of contamination produce malassezia colonization and
infections.
F.
Bacteria in breast milk are morphologically
different than bacteria in amniotic fluid, placenta, meconium and umbilical
cord blood and they are not contaminants(20-25). Also breast milk contains essential organic matter for life and ,empirical
observations suggest unrefrigerated sterilized eggs and milk go sour(this
observation has not been experimentally validated ). These observations suggest
, bacteria in breastmilk result from transformation of organic matter.
G.
Mathematical evidence suggest the probability of
pathways independent of contamination to cause burn wound infections is %
99.9999.(26)
Collectively, the evidence indicate infections
result from contamination or by transformation of organic matter of human
tissues to microbes. This observation may promote new insights into the complex
relations among living and nonliving things.
References :
1.Pasteur L. And the extension of the germ theory to the
aetiology of certain common diseases. Comptes rendus del’Academie des Sciences.xc.Ernst,(Ttrans).1880;1033-44.H.C.
2. Marshall BJ, Warren JR (June 1984). "Unidentified
curved bacilli in the stomach of patients with gastritis and peptic
ulceration". Lancet. 1 (8390): 1311–5.
3. .Salerian A.J.,Human body may produce bacteria. Medical
Hypotheses, 103: 130-132, June 2017 .
4. . Schopf J.W.,Fossil evidence of Arcaean Life,
philosophical transactions of the Royal Society biological sciences. June 29,
2006. Volume 361, issue 1470.
5. Cavalier-Smith T.,
Cell evolution and Earth history :Stasis and revolution. Philosophical
transactions Royal Society in London biological sciences. 2006 June 29;; three
six one(1470) 969 – 1006.
6. Altermann W., Kazmieczak J., .Archean Micro
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Volume 154, issue 9, November 2003 page
is 611 – 617.
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Bradley R., Asher D.M.,Detwiler L., Bovine spongiform encephalopathy and
variant Creutzfeldt- Jacob disease:
background evolution and current concerns, emerging infectious diseases
volume 7 number 1, January – February 2001.
8. HAY,
L. J. ; VARCO,
R. L. ; CODE,
C. F. ; WANGENSTEEN,
O. H.The experimental production of gastric and duodenal ulcers in
laboratory animals by the intramuscular injection of histamine in beeswax.
: Surgery,
Gynecology and Obstetrics 1942 Vol.75 pp.170-182.
9.Huang J-Q.,Sridhar S.,Hunt R., Role of helicobacteri
infection and none steroidal anti-inflammatory drugs in peptic ulcer disease;
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10. Perri F.,Pastore M.,Rocco C.,et al.,Helicobacteri pyloriinfection may undergo spontaneous
eradication in children:A2 year follow up study. Journal of pediatric
gastroenterology and nutrition. 27(2): 181-183, August 1998.
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spontaneous illumination helicobacter pylori infection :clinical implications.
American Journal of gastroenterology October 1997 volume 92 issue 10 Pages 1780
– 1787.
12. Morgan A. G., McAdam, W A., Pacsoo, C.,
Walker B.E., Simmons A.V.,
Cimetidine: an
advance in gastric ulcer treatment? Br Med J 1978;2:
13. Isenberg,J.I.,, Peterson,W.L., Elashoff,J.D.,
Sandersfeld,M.A.,et.al., Healing of Benign Gastric Ulcer with Low-Dose Antacid
or Cimetidine — A DoubleBlind, Randomized, Placebo-Controlled Trial, N
Engl J Med 1983; 308:1319-1324
14, Khatchataryan Z.A.,Ktsoyan Z.A.,Manukyan G.P.,Kelly
D.,Ghazaryan K.A.,Aminov R.I., predominant role of host genetics in controlling
the composition of gut .microbiota.PLoS One 2008;3:e3064.
15.He S.M., Du W.D., Yang S., Zhou S.M., Li W., Wang J.,
Xiao F.L., Xu S.X., Zhang X.J., The genetic epidemiology of tinea versicolor in
China. Mycosis/ volume 51/ issue one. October 2007.
16. Hafez Ma · El-Shamy SB , Genetic Susceptibility in
Pityriasis versicolor, Dermatologica 1985;171:86–88.
17 Burke,R., Tinea Versicolor:
susceptibility factors in experimental infection in human beings. Journal of
investigative dermatology. 1961, volume 36 number 5, Pages 389 – 401.
18. Digiullo D.B., .Diversity of microbes in amniotic fluid. Seminars
in fetal and neonatal medicine. Volume 17, issue 1, February 2012 pages 2
19. Capone K.A.,Dowd S.E.,Stamatas G.N.,Nikolovski J.,Diversity
of the human skin microbiome early in life.J Invest Dermatolo
,2011.131(10)206-2032.
20.
Cabanes F.J(2014),Malassezia yeasts:how many species infect
humans and animals ?PLOS Pathogens,10(2):e1003892.
21.
Faergemann J., Fredricksson T., Experimental
infections in rabbits and humans with Pityrosprum orbiculare and P.ovale.
Journal of Investigative Dermatology. Volume 77 issue 3, September 1981, Pages
314 – 318.
22.
FaergemannJ.,AlyR.,WilsonD.R.,MaibachH.I.,;Skinocclusion:effectonPityrosprum
orbiculare,skinP-CO2,ph, trans epidermal water loss, and water content.
Archives of dermatological research. November 1983, volume 275, issue 6, pages
383 – 387.
23.
Cabrera-Rubio R., Collado M.C.,Laitenen K.,
Salminen S., Isolauri E., The human milk microbiome changes over lactation and
is shaped by maternal weight and mode of delivery. The American Journal of
clinical nutrition volume 96, issue 3, September 2012, page is 544 four four–
551.
24.
Martin
R.,Langa S., Revriego C., et al .Human milk is a source of lactic acid bacteria
for the infant gut. The Journal of pediatrics. December 2003, volume 143, issue
six, Page is 754 – 758
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Urbaniaak,C.et al. Microbiota in human breast tissue. Appl.Environ.
Microbiology 80, 3007 – 3014(2014).
26.
.Salerian A.J., pathways independent of
contamination may produce burn wound infections. Biomedical Journal of
scientific and technical research. Volume 8-issue five:2018.
